HERMAN BEERMAN LECTURE
Network Biology of normal skin, inflammation & cancer
Allan Balmain MD PhD
Dr. Allan Balmain obtained his PhD in chemistry at the University of Glasgow, Scotland, and carried out post-doctoral research in France and Germany before returning to Scotland where he was the Jerry Turner Fellow of the Cancer Research Campaign and Professor of Cancer Genetics at the Beatson Institute, and Director of Laboratory Research in the Department of Medical Oncology at the University of Glasgow. He moved to the United States in 1997 to a position as Vice President of Research at Onyx Pharmaceuticals in San Francisco, California. Allan Balmain currently holds the Barbara Bass Bakar Distinguished Professorship in Cancer Genetics at the University of California, San Francisco. He is Co-Director of the Cancer Genetics Program and Director of the Genome Core Facility at UCSF Cancer Center. He is a member of the Board of Scientific Overseers of The Jackson Laboratory, Bar Harbor, and on several External Advisory Boards in the US and Europe. Awards and Honours include election to Fellowship of the Royal Society of Edinburgh (1995), the Tom Connors Prize and Lecture from the BACR (2000), the DiMaggio Lecture from Dana Farber Cancer Center (2004), The Cori Award from Roswell Park Cancer Center (2007), the John B. Little Award from Harvard School of Public Health (2007), and the American Skin Association Achievement Award (2011). .Dr. Balmain’s main research interests have been the elucidation of the genetic basis of multistage carcinogenesis, with particular emphasis on mouse models of chemically induced skin tumor development. His strategy has been to identify the sequence of somatic genetic alterations, which are associated with discrete stages of tumorigenesis: initiation, promotion, progression to locally invasive lesions and development of metastases. His group has also identified genes and pathways associated with cancer susceptibility in different mouse strains and in human populations. His research at present is focused on systems approaches to analysis of cancer susceptibility and progression using computational biology and gene network analysis.
Wakabayashi Y, Mao JH, Brown K, Girardi M, Balmain A. Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice. Nature.
2007; 445(7129):761-5. PMID: 17230190
Wei G, Ku S, Ma GK, Saito S, Tang AA, Zhang J, Mao JH, Appella E, Balmain A, Huang EJ. HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis. Proc Natl Acad Sci U S A
. 2007 Aug 7;104(32):13040-5. Epub 2007 Jul 31. PMCID: PMC1936219
Quigley DA, To MD, Pérez-Losada J, Pelorosso FG, Mao JH, Nagase H, Ginzinger DG, Balmain A. Genetic architecture of mouse skin inflammation and tumour susceptibility. Nature.
2009 458. 505-8. PMID 19136944
Quigley DA, Balmain A. Systems Genetics Analysis of cancer susceptibility:from mouse models to humans. Nat Rev Genet
2009 Sep;10(9):651-7. Epub 2009 Jul 28. PMID: 19636343
Chun MG, Mao JH, Chiu CW, Balmain A, Hanahan D. Polymorphic genetic control of tumor invasion in a mouse model of pancreatic neuroendocrine carcinogenesis. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17268-73. Epub 2010 Sep 20. PMID: 20855625
Quigley DA, To MD, Kim IJ, Lin KK, Albertson DG, Sjolund J, Perez-Losada J, Balmain A. Network analysis of skin tumor progression identifies a rewired genetic architecture affecting inflammation and tumor susceptibility. Genome Biol. 2011 Jan 18;12(1):R5. PMID: 21244661
Wang YV, Leblanc M, Fox N, Mao JH, Tinkum KL, Krummel K, Engle D, Piwnica-Worms D, Piwnica-Worms H, Balmain A, Kaushansky K, Wahl GM. Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes Dev. 2011 Jul 1:25(13);1426-38. PMID: 21724834
Mao JH, Wu D, Kim IJ, Kang HC, Wei G, Climent J, Kumar A, Pelorosso FG, Delrosario R, Huang EJ, Balmain A. Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma. Oncogene. 2011 Jul 25. PMID:21785465.
Kang HC, Quigley D, Kim IJ, Wakabayashi Y, Ferguson-Smith MA, D’Alessandro M, Lane EB, Akhurst R, Goudie DR, Balmain A. Multiple Self-Healing Squamous Epithelioma (MSSE): rare variants in an adjacentregion of chromosome 9q22.3 to known TGFBR1 mutations suggest a digenic or multilocus etiology. Journal of Investigative Dermatology, in press.
Kang HC, Wakabayashi Y, Jen KY, Mao JH, Zoumpourlis V, Del Rosario R and Balmain A. Ptch1 Overexpression Drives Skin Carcinogenesis and Developmental Defects in K14PtchFVB Mice. Journal of Investigative Dermatology, in press.