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Scientific Program

SID RISING STAR LECTURE

Human skin resident memory T cells: The ups and downs of on-site immunity

Rachael A. Clark MD PhD



Rachael Clark is a dermatologist and an immunologist and an Associate Professor of Dermatology at Harvard Medical School. Dr. Clark’s laboratory focuses on the study of tissue resident memory T cells in health and disease. Her research is carried out largely on human cells and tissues, focuses on problems identified in clinical practice and has the dual goals of improving treatments for skin diseases while at the same time providing novel insights into human immune responses

Selected Publications:

Clark, R. A., B. F. Chong, N. Mirchandani, K. Yamanaka, G. S. Murphy, R. Dowgiert, and T. S. Kupper. 2006. A novel method for the isolation of skin resident T cells from normal and diseased human skin. Journal of Investigative Dermatology. 16 February; doi: 10.1038/sj.jid.5700199.

Clark, R. A., B. F. Chong, N. Mirchandani, N. Brinster, K. Yamanaka, R. Dowgiert, and T. S. Kupper. 2006. The vast majority of CLA+ T cells are resident in normal skin. Journal of Immunology. 176:4431-4439.

Clark RA, Kupper TS. 2007. IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin. Blood. 109, 194-202.

Clark RA, Huang SJ, Murphy GF, Mollet IG, Hijnen D., Muthukuru M, Schanbacher CF, Edwards V.,  Miller DM, Kim JE, Lambert J., & Kupper TS. 2008. Human squamous cell carcinomas evade the immune response by downregulation of vascular E-selectin and recruitment of regulatory T cells. Journal of Experimental Medcine. 205:2221-2234. PMCID: PMC2556796.

Huang SJ, Hijnen D., Murphy GF, Kupper TS, Calarese, AW., Mollet IG., Schanbacher CF, Miller DM, Schmults C. & Clark RA. 2009. Imiquimod enhances IFN-g production and effector function of T cells infiltrating human squamous cell carcinomas of the skin. Journal of Investigative Dermatology. 1523-1747 (Electronic). PMCID: PMC2841955.

Clark, RA, Shackelton, JB, Watanabe, R, Calarese, A, Yamanaka, K, Campbell, JJ, Teague, JE, Kuo, HP, Hijnen, D, Kupper, TS. 2011. High Scatter T cells: a reliable biomarker for CTCL. Blood. First Edition Paper, prepublished online December 9, 2010; DOI 10.1182/blood-2010-05-287664.  PMCID: PMC3056643.

Clark, R.A. , Watanabe R., Teague J.E., Schlapbach C., Tawa M.C., Adams N., Dorosario A.A., Chaney K.S., Cutler C.S., LeBoeuf N.R., Carter J.B., Fisher D.C., Kupper T.S. 2012. Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab treated CTCL patients. Science Translational Medicine. 4, 117ra117 (2012). PMCID: PMC3373186.

Jiang, X., Clark, R.A., Liu, L., Wagers, A.J., Fuhlbrigge, R.C., Kupper, T.S. 2012. Skin infection generates non-migratory memory CD8+ T cells providing global skin immunity. Nature. 483:227-231. PMCID: PMC3437663

Gehad, A., Lichtman, M., Schmults, C., Teague, J.E., Calarese, A., Jiang, Y., Watanabe, R. and Clark, R.A. 2012. Nitric oxide-producing myeloid-derived suppressor cells inhibit vascular E-selectin expression in human squamous cell carcinomas. Journal of Investigative Dermatology. 132(11):2642-51.PMCID: PMC3449043.

Dowlatshahi, M., Huang, V., Gehad, A., Jiang, Y., Calarese, A., Teague, J.E., Dorosario, A., Cheng, J., Nghiem, P., Schanbacher, C., Thakuria, M., Schmults, C., Wang, L., and Clark, R.A. 2013. Tumor-specific T cells in human Merkel cell carcinomas: a possible role for Tregs and T cell exhaustion in reducing T cell responses. Journal of Investigative Dermatology. Epub ahead of print.  PMC submission pending.

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